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Long term oxygen therapy(LTOT)
refers to providing supplemental oxygen to the Chronic hypoxaemia
patients( including Sleep and Motility hypoxemia), and lasting for a long time.
Most of scholars agree that the time shall be at least 6 months. The standard
long term oxygen therapy shall be 24 h/d, says continuously oxygen therapy.
However, some patients are hard to finish it, so when breathing supplemental
oxygen for above 18 hours everyday, we call continuously oxygen therapy. When taking
12 hours only at night(including sleeping) everyday, we call Night oxygen
therapy.
To get a good effect of the oxygen
therapy, the current consensus is taking at least 15 hours supplemental oxygen and make
the Pao2 reach 60mmHg.
So why shall we carry out the long
term oxygen therapy ?
As along with the process of COPD,
many patients are with the hypoxaemia conditions, and the PaO2 of most patients
is decreasing by 1.33mmHg every year. The low hypoxaemia and hypercapnia will
make the pulmonary muscularized arteries spasm and increase the resistance of
the pulmonary circulation, then it will form the Pulmonary hypertension,
finally leads to the heart disease. The spasm of pulmonary small artery is the
main cause for the dramatic increase in pulmonary artery pressure when the
chronic pulmonary patients are under acute exacerbation.
By improving the hypoxaemia, the pulmonary
artery pressure can go down. It is good to the disease. If not, it will make
the vessel narrow and fibrosis because of the continuously spasm and PAH. Also,
as the quantity of the lung capillary bed decreases and the pulmonary circulation
resistance increases, the pulmonary artery pressure will increase continuously,
it’ll make the right heart work overload, finally resulting in heart failure.
Stop smoking, anti-infection, diastole bronchus are the some
important methods to improve and control the symptoms, but LTOT is the main
factor to effect the Cor pulmonale prognostic.
To those with severe hyoxemia (PaO2<60mmHg),
there are many benefits by carrying out the LTOT:
Improve the survival rate
Prevent deterioration of pulmonary
hypertension
Decrease the incidence of polycythemia
Improve the sleep quality
Increase the renal blood flow
Reduce the incidence of arrhythmia
We suggest that the patient shall
carry out the LTOT with below two factors:
1.
The PaO2< 50mmHg or between
50~60mmHg when under rest state
2.
There is one of the following
symptoms: secondary polycythemia/ Hypoxia at night/ Peripheral oedema/ Pulmonary hypertension.
Evaluation index for LTOT
Indications
|
Specific performance
|
Severe COPD
Tissue hypoxia
Right heart failure
|
FEV1<40%
Labial surface cyanosis
Polycythemia (Hematocrit increased)
Confusion during acute infection
arterial oxygen saturation < 92%
arterial PaCo2> 50mmHg
Peripheral oedema
Jugular vein pressure increases
fluid collection and gain the weight
|
To get a good effect, the time to
breath supplemental oxygen shall be at least above 15 hours. The flow is
between 1~3L/min to avoid inhibiting the respiration and the aggravating carbon
dioxide retention
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