Thursday, December 18, 2014

Lovego weekly report-The role of airway inflammation in COPD

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Weekly report

The role of airway inflammation in COPD

COPD, which is caused by long-term inhalation of toxic gases and particles, is a disease characterized by airflow limitation that is not fully reversible, showing a progressive decline in FEV1, increasing shortness of breath, and ultimately respiratory failure. The airflow limitation is with gradually development. Smoking is the main reasons as well as the air pollution, bedroom environment pollution and some occupational factors. The pathophysiology caused by these factors are very similar, that is airway inflammation.

Airway inflammation is a key part to COPD, leads to nearly all the changes of structure and function.

The airway remodeling is the result made by the repeated abnormal repair from chronic inflammatory injury of small airway,
Destruction of lung parenchyma(emphysema) is caused by the protease released by pulmonary inflammatory cells.
The Glands hyperplasia and high production is resulted from the protease/ Proinflammatory mediators/ oxide released by inflammatory cells.
The prominent features for Acute exacerbation phase of COPD is the aggravating and magnified of airway inflammation.

Thus we know ,the airway inflammation acts a leading role during the progression of COPD. It is a ongoing problem in the lungs, there are no effective measures to eliminate it, even quit smoking.




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